منابع مشابه
Antidepressants as analgesics: an introduction.
Tricyclic and certain other antidepressants are widely used to treat chronic and neuropathic pain states. The first report of such activity appeared 40 years ago, soon after the introduction of tricyclic antidepressants into clinical medicine. Their efficacy in this regard is now well established through both clinical trials, as well as systematic and meta-analysis approaches. Although the mech...
متن کاملNarcotic analgesics as adjuncts to dental practice.
Pain is both a symptom and a sensation. As a symptom, pain signals danger and thus provokes appropriate reflexes. Sher rington,2 accordingly, described pain as “the psychical adjunct of an imperative protective reflex.” From a therapeutic viewpoint, pain is a valuable clinical symptom to the practitioner. It also follows that the management of pain— a symptom— must be subject to the same limit...
متن کاملRecent Findings Surrounding Topical Antidepressants as Analgesics and Review of Existing and Emerging Topical Analgesics*
Tricyclic antidepressants (TCAs) have been used for chronic pain management for decades; however, their potential use as topical analgesics is an area of new research. This article highlights recent findings relating to the mode of action of TCAs and summarizes results of animal testing of these agents as analgesics. A review of existing and emerging information regarding localized peripheral a...
متن کاملMu-conotoxins as leads in the development of new analgesics.
Voltage-gated sodium channels (VGSCs) contain a specific binding site for a family of cone shell toxins known as mu-conotoxins. As some VGSCs are involved in pain perception and mu-conotoxins are able to block these channels, mu-conotoxins show considerable potential as analgesics. Recent studies have advanced our understanding of the three-dimensional structures and structure-function relation...
متن کاملOpioid Analgesics
Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...
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ژورنال
عنوان ژورنال: Nature
سال: 1960
ISSN: 0028-0836,1476-4687
DOI: 10.1038/188972a0